History suggests the Buffalo Bills don’t fare well outside of the United States, but they’ve never played an international game with Sean McDermott as coach or Josh Allen as quarterback.

Sunday’s game at Tottenham Hotspur Stadium in north London will be Buffalo’s first game in England since 2015. That year’s 34-31 loss to Jacksonville at Wembley Stadium was Buffalo’s first trip overseas. But in the decade prior, the Bills played six games from 2008-13 in the since-canceled Toronto Series, going 1-5. The lone win? A 23-0 shutout of Washington in 2011.

So no, international games probably don’t bring back fond memories for Bills fans of the playoff drought era.

But this year’s London trip finds the Bills in a much different position than the 2015 team that also took on Jacksonville. The Bills are — to borrow an English soccer, erm, football term — top of the table in the AFC East and the conference overall, one of four AFC teams to start 3-1, along with the Dolphins, Ravens and Chiefs.

Last week’s 48-20 win over Miami at Highmark Stadium firmly reestablished the Bills as division favorites, but it only takes one bad week to change that conversation.

While the Bills are favored in the neutral site “home” game (5.5-point spread), there’s plenty of reason to think Jacksonville, with a Super Bowl-winning coach (Doug Pederson) and No. 1 overall pick quarterback (Trevor Lawrence), could give Buffalo a good game.

— On the injury front, the Bills’ defense will continue to test its depth. They are of course without Tre’Davious White after his season-ending Achilles tear last week, and defensive end Greg Rousseau is out with a foot injury. Jordan Poyer, who missed last week with a knee injury, is set to return while cornerback Christian Benford is questionable. Pass rushing star Von Miller could make his debut off the PUP list as a limited participant all week. On Friday, Miller estimated he has a “94.5%” chance and a “safe bet” to play, but he is officially listed as questionable.

— The Bills are playing a Jacksonville team that entered the year as heavy favorites to repeat as AFC South champions. But that division picture has yet to settle with all four teams at 2-2 through four weeks.

Playing in London for a second consecutive week (a first for any NFL team) after a 23-7 win over the Falcons last week at Wembley, the Jaguars would seem to have a travel advantage. They’ve stayed in London since last week, while the Bills flew out on Thursday. With a five-hour time zone difference, the Bills have the rest of the weekend to adjust their sleep schedules.

“Those are the things we can’t control, the number of games they’ve played here, their comfort level, them being here a full week ahead of us or so, a week and a half maybe,” McDermott told reporters Friday. “We focus on the things we can control and once we get into the moment we’re going to be competing and that’s really what you do.”

While McDermott called it “an honor” to be one of the teams selected for the NFL International Series it presents some challenges for coaches who typically obsess over details.

The Bills emphasized rest on their flight.

“I heard the flight attendants were commenting, one flight attendant in particular had been through a number of overseas trips with the NFL teams and said this was the quietest team that he had heard,” McDermott said.

The Bills held meetings Friday and a walk-through practice, a change from their normal Friday routine of a “full-speed” practice, which McDermott attributed to “the lack of sleep perhaps for some guys on the plane” Thursday night.

“(We) just wanted to get them moving but in a walk-through pace and allow them to get a little bit of the mental work that we need as well,” McDermott said.

It’s the first international game trip for McDermott as well as the majority of Bills players.

Of course, the Bills are familiar with unusual travel schedules. Last year, they relocated a home game to Detroit during a snowstorm that made playing in Orchard Park impossible.

“At the end of the day, on Sunday, it’s the same game that we’ve been playing for however many long years, since we were kids, it’s the same game of football,” Allen said. “We have a lot of leadership on this team that have been through certain types of situations … last year and different types of environments.”

A “caffeined-out” Allen had plenty of coffee Friday but admitted he was tired at the news conference having not gotten much sleep before going into meetings.

“But come Sunday, it’s whoever’s going to execute the best, and we’ve been listening to our sports science staff that’s in-house and trusting what they’re saying and just trying to make sure that our body clocks are aligned to the time zone here and to get as much ready as we can to go on Sunday.”